Fujicalin® is a dibasic calcium phosphate anhydrous designed to function as a direct compression excipient.
It has exceptional flow and compression characteristics while maintaining the ability for rapid disintegration.
The key to Fujicalin®’s superior performance is the highly specialized and proprietary manufacturing process that yields a unique primary particle.
The patented manufacturing process yields porous spheres with high specific surface area. Fujicalin® is totally synthetic and ideally suited to direct compression formulations, especially involving difficult-to-compress materials like oily actives.
It can also be used to assist flow, reduce tablet weight variation and improve content uniformity.
Fujicalin®’s compressibility facilitates the design of smaller tablets. It can also be used as a partial or total replacement for microcrystalline cellulose.
|White Crystalline Powder
|Mean particle size(µm)
|Angle of repose(°)
|Angle of spatula(°)
|BET surface area(m²/g)
|Oil adsorption capacity(ml/g)
|Water adsorption capacity(ml/g)
|Loss on drying
*Carr value calculated adding relevant index points. Higher value indicates better powder flor properties
(Ref-Carr,R.L., Chem. Eng., 1965; 72(3), 163-168)
Unique attributes of Fujicalin®
Anhydrous Dibasic Calcium Phosphate is generally used as an excipient with low reactivity due to its neutral pH in the aqueous suspension. It also as a high bulk density and is not moisture sensitive as other excipients.
However, compressibility of conventional anhydrous calcium hydrogen phosphate are not sufficient for the direct compression.
Fujicalin® has a spherical granule formed by spray-drying. It is also synthesized by a unique crystal growth control method. Fujicalin® has a crystalline structure of anhydrous calcium hydrogen phosphate, but the X-ray analysis pattern is broad due to the unique synthesis process. The primary particles are fine and plate-like.
With spray drying, plate-like crystals form a card house structure and resulting in granules with a large porosity. This structure produces the characteristics of Fujicalin (compressibility and oil absorption) that a conventional anhydrous dibasic calcium phosphate does not have, and is particularly suitable for direct compression.
Comparison of physical properties with conventional DCPA’s and DCPD
|DCPA ( dibasic calcium phosphate, anhydrous )
(dibasic calcium phosphate, dihydrate)
|Average particle size*
|Angle of Repose
|BET Surface area
|Oil Adsorption Capacity
Comparison of tablet hardness with conventional DCPA’s and DCPD
DCPA：dibasic calcium phosphate, anhydrous
DCPD：dibasic calcium phosphate, dihydrate
- Fujicalin® retains porosity at high compression forces and exhibits low friability across broad compression range
- High porosity is maintained after compression
- Highly flowable and promotes content uniformity
- It can improve disintegration by triggering capillary action. With a right disintegrant, it can create fast disintegration tablets.
- Fujicalin®’s smooth and spherical granules are less abrasive on tableting machines leading to trouble free operations.
Application of Fujicalin®
Fujicalin is used for these applications utilizing the aforementioned attributes
- Fujicalin® makes sufficiently hard tablets at low compression forces, and it has a very low water content in addition. It is an ideal excipient for manufacturing tablets of probiotic preparations
- disintegration tablets using Fujicalin have already been launched commercially. Fujicalin has ability to promote disintegration.
- Fujicalin® is ideal as a carrier for Self-Emulsifying Drug Delivery System (SEDDS) and solid dispersion including Hot Melt Extrusion (HME).
- There have been roller compaction applications utilizing Fujicalin and micro crystalline cellulose