Fujicalin® -unique DCPA

Fujicalin® is a dibasic calcium phosphate anhydrous designed to function as a direct compression excipient.

It has exceptional flow and compression characteristics while maintaining the ability for rapid disintegration.
The key to Fujicalin®’s superior performance is the highly specialized and proprietary manufacturing process that yields a unique primary particle.
The patented manufacturing process yields porous spheres with high specific surface area. Fujicalin® is totally synthetic and ideally suited to direct compression formulations, especially involving difficult-to-compress materials like oily actives.
It can also be used to assist flow, reduce tablet weight variation and improve content uniformity.
Fujicalin®’s compressibility facilitates the design of smaller tablets. It can also be used as a partial or total replacement for microcrystalline cellulose.

General Properties

Properties Fujicalin®
Appearance White Crystalline Powder
Mean particle size(µm) 120
Bulk density(g/ml) Loose 0.46
Tapped 0.54
Compressibility index 15.1
Angle of repose(°) 29.5
Angle of spatula(°) 33.3
Carr value* 86.5
BET surface area(m²/g) 40
Oil adsorption capacity(ml/g) 1.1
Water adsorption capacity(ml/g) 1.2
Loss on drying 0.5
Flowability Excellent
Watter activity 0.11

*Carr value calculated adding relevant index points. Higher value indicates better powder flor properties
(Ref-Carr,R.L., Chem. Eng., 1965; 72(3), 163-168)


Unique attributes of Fujicalin®

Anhydrous Dibasic Calcium Phosphate is generally used as an excipient with low reactivity due to its neutral pH in the aqueous suspension. It also as a high bulk density and is not moisture sensitive as other excipients.

However, compressibility of conventional anhydrous calcium hydrogen phosphate are not sufficient for the direct compression.

Fujicalin® has a spherical granule formed by spray-drying. It is also synthesized by a unique crystal growth control method. Fujicalin® has a crystalline structure of anhydrous calcium hydrogen phosphate, but the X-ray analysis pattern is broad due to the unique synthesis process. The primary particles are fine and plate-like.

With spray drying, plate-like crystals form a card house structure and resulting in granules with a large porosity. This structure produces the characteristics of Fujicalin (compressibility and oil absorption) that a conventional anhydrous dibasic calcium phosphate does not have, and is particularly suitable for direct compression.

Outer appearance

Outer appearance

Internal Structure

Internal Structure



Comparison of physical properties with conventional DCPA’s and DCPD

Property DCPA ( dibasic calcium phosphate, anhydrous ) DCPD
(dibasic calcium phosphate, dihydrate)
Fujicalin Conventional DCPA
Average particle size* 120μm 45μm 127μm
Bulk Density(Loose) 0.46g/mL 0.77g/mL 0.83g/mL
Bulk Density(Tapped) 0.54mg/mL 1.11g/mL 0.91g/mL
Angle of Repose 30° 42° 35°
BET Surface area 40m²/g 0.7m²/g 0.57m²/g
Oil Adsorption Capacity 1.1mL/g 0.4mL/g 0.2mL/g
Water Adsorption 1.2mL/g 0.5mL/g 0.2mL/g

*Sieving Method


Comparison of tablet hardness with conventional DCPA’s and DCPD

Compressibility comparison between Fujicalin and other DCPAs

DCPA:dibasic calcium phosphate, anhydrous
DCPD:dibasic calcium phosphate, dihydrate



  • Fujicalin® retains porosity at high compression forces and exhibits low friability across broad compression range
  • High porosity is maintained after compression
  • Highly flowable and promotes content uniformity
  • It can improve disintegration by triggering capillary action. With a right disintegrant, it can create fast disintegration tablets.
  • Fujicalin®’s smooth and spherical granules are less abrasive on tableting machines leading to trouble free operations.


Application of Fujicalin®

Fujicalin is used for these applications utilizing the aforementioned attributes

  • Fujicalin® makes sufficiently hard tablets at low compression forces, and it has a very low water content in addition. It is an ideal excipient for manufacturing tablets of probiotic preparations
  • disintegration tablets using Fujicalin have already been launched commercially. Fujicalin has ability to promote disintegration.
  • Fujicalin® is ideal as a carrier for Self-Emulsifying Drug Delivery System (SEDDS) and solid dispersion including Hot Melt Extrusion (HME).
  • There have been roller compaction applications utilizing Fujicalin and micro crystalline cellulose